Genetic polymorphisms of NOS2 and predisposition to fracture non-union: A case control study based on Han Chinese population.

ABSTRACT: A non-union, especially atrophic non-unions, is a permanent failure of healing following a fracture and can be difficult to treat. Approximately 5-10% of fractures will result in a non-union during the healing process. non-unions can be classified into two types: atrophic non-union which is often due to impaired bone healing with a potential biological mechanism, and hypertrophic non-union which is due to inadequate fixation after fracture. Genetic variations also play an important role in the fracture healing response. Previous studies based on animal models have indicated that NOS2 might be greatly involved in the bone fracture healing process. In this case-control study, 346 nonunion patients were compared to 883 patients with normal fracture healing to investigate the potential genetic

SUBMITTER: Huang W 

PROVIDER: S-EPMC5843262 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature