Human dengue virus serotype 2 neutralizing antibodies target two distinct quaternary epitopes.

ABSTRACT: Dengue virus (DENV) infection causes dengue fever, dengue hemorrhagic fever and dengue shock syndrome. It is estimated that a third of the world's population is at risk for infection, with an estimated 390 million infections annually. Dengue virus serotype 2 (DENV2) causes severe epidemics, and the leading tetravalent dengue vaccine has lower efficacy against DENV2 compared to the other 3 serotypes. In natural DENV2 infections, strongly neutralizing type-specific antibodies provide protection against subsequent DENV2 infection. While the epitopes of some human DENV2 type-specific antibodies have been mapped, it is not known if these are representative of the polyclonal antibody response. Using structure-guided immunogen design and reverse genetics, we generated a panel of recombinant virus

SUBMITTER: Gallichotte EN 

PROVIDER: S-EPMC5843351 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature