Differential tissue growth and cell adhesion alone drive early tooth morphogenesis: An ex vivo and in silico study.

ABSTRACT: From gastrulation to late organogenesis animal development involves many genetic and bio-mechanical interactions between epithelial and mesenchymal tissues. Ectodermal organs, such as hairs, feathers and teeth are well studied examples of organs whose development is based on epithelial-mesenchymal interactions. These develop from a similar primordium through an epithelial folding and its interaction with the mesenchyme. Despite extensive knowledge on the molecular pathways involved, little is known about the role of bio-mechanical processes in the morphogenesis of these organs. We propose a simple computational model for the biomechanics of one such organ, the tooth, and contrast its predictions against cell-tracking experiments, mechanical relaxation experiments and the observed tooth sha

SUBMITTER: Marin-Riera M 

PROVIDER: S-EPMC5843354 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature