Comparison of ferumoxytol-based cerebral blood volume estimates using quantitative R1 and R2* relaxometry.

ABSTRACT: PURPOSE:Cerebral perfusion is commonly assessed clinically with dynamic susceptibility contrast MRI using a bolus injection of gadolinium-based contrast agents, resulting in semi-quantitative values of cerebral blood volume (CBV). Steady-state imaging with ferumoxytol allows estimation of CBV with the potential for higher precision and accuracy. Prior CBV studies have focused on the signal disrupting T2* effects, but ferumoxytol also has high signal-enhancing T1 relaxivity. The purpose of this study was to investigate and compare CBV estimation using T1 and T2*, with the goal of understanding the contrast mechanisms and quantitative differences. METHODS:Changes in R1 (1/T1 ) and R2* (1/ T2*) were measured after the administration of ferumoxytol using high-resolution quantitative approaches

SUBMITTER: Rivera-Rivera LA 

PROVIDER: S-EPMC5843511 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature