Compressed sensing in quantitative determination of GAG concentration in cartilage by microscopic MRI.

ABSTRACT:

Purpose

To evaluate the potentials of compressed sensing (CS) in MRI quantification of glycosaminoglycan (GAG) concentration in articular cartilage at microscopic resolution.

Methods

T₁ -weighted 2D experiments of cartilage were fully sampled in k-space with five inversion times at 17.6 μm resolution. These fully sampled k-space data were re-processed, by undersampling at various 1D and 2D CS undersampling factors (UFs). The undersampled data were reconstructed individually into 2D images using nonlinear reconstruction, which were used to calculate 2D maps of T₁ and GAG concentration. The values of T₁ and GAG in cartilage were evaluated at different UFs (up to 16, which used 6.25% of the data). K-space sampling pattern and zonal variations we

SUBMITTER: Wang N 

PROVIDER: S-EPMC5843514 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature