Vascular input function correction of inflow enhancement for improved pharmacokinetic modeling of liver DCE-MRI.

ABSTRACT: PURPOSE:To propose a simple method to correct vascular input function (VIF) due to inflow effects and to test whether the proposed method can provide more accurate VIFs for improved pharmacokinetic modeling. METHODS:A spoiled gradient echo sequence-based inflow quantification and contrast agent concentration correction method was proposed. Simulations were conducted to illustrate improvement in the accuracy of VIF estimation and pharmacokinetic fitting. Animal studies with dynamic contrast-enhanced MR scans were conducted before, 1 week after, and 2 weeks after portal vein embolization (PVE) was performed in the left portal circulation of pigs. The proposed method was applied to correct the VIFs for model fitting. Pharmacokinetic parameters fitted using corrected and uncorrected VIFs were

SUBMITTER: Ning J 

PROVIDER: S-EPMC5843520 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature