Plasma Cell Depletion Attenuates Hypertension in an Experimental Model of Autoimmune Disease.

ABSTRACT: Numerous studies show a direct relation between circulating autoantibodies, characteristic of systemic autoimmune disorders, and primary hypertension in humans. Whether these autoantibodies mechanistically contribute to the development of hypertension remains unclear. Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by aberrant immunoglobulin production, notably pathogenic autoantibodies, and is associated with prevalent hypertension, renal injury, and cardiovascular disease. Because plasma cells produce the majority of serum immunoglobulins and are the primary source of autoantibodies in SLE, we hypothesized that plasma cell depletion using the proteasome inhibitor bortezomib would lower autoantibody production and attenuate hypertension. Thirty-week-old f

SUBMITTER: Taylor EB 

PROVIDER: S-EPMC5843526 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature