RTS,S malaria vaccine efficacy and immunogenicity during Plasmodium falciparum challenge is associated with HLA genotype.

ABSTRACT: Although RTS,S remains the most advanced malaria vaccine, the factors influencing differences in vaccine immunogenicity or efficacy between individuals or populations are still poorly characterised. The analyses of genetic determinants of immunogenicity have previously been restricted by relatively small sample sizes from individual trials. Here we combine data from six Phase II RTS,S trials and evaluate the relationship between HLA allele groups and RTS,S-mediated protection in controlled human malaria infections (CHMI), using multivariate logistic or linear regression. We observed significant associations between three allele groups (HLA-A^∗01, HLA-B^∗08, and HLA-DRB1^∗15/^∗16) and protection, while another three allele groups (HLA-A^∗03,

SUBMITTER: Nielsen CM 

PROVIDER: S-EPMC5843576 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature