CD24 aggravates acute liver injury in autoimmune hepatitis by promoting IFN-γ production by CD4⁺ T cells.

ABSTRACT: The T-cell-mediated immune response is implicated in many clinical hepatic injuries, such as autoimmune hepatitis and acute virus hepatitis. CD24 is widely expressed by different immune cells and plays an important role in the pathogenesis of many autoimmune diseases. However, the role of CD24 in T-cell-mediated liver injury has not been elucidated until now. Here we showed that CD24 deficiency protects mice from concanavalin A (ConA)-induced fulminant liver injury by reducing serum interferon-γ (IFN-γ) levels. CD24 expression by hepatic T cells was markedly increased following ConA challenge. Moreover, decreased IFN-γ production by hepatic CD4⁺ T cells in CD24-deficient mice was detected, which was correlated with downregulated phosphorylation of STAT1 in hepatic tissue. In vit

SUBMITTER: Zheng C 

PROVIDER: S-EPMC5843612 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature