GABA_a excitation and synaptogenesis after Status Epilepticus - A computational study.

ABSTRACT: The role of GABAergic neurotransmission on epileptogenesis has been the subject of speculation according to different approaches. However, it is a very complex task to specifically consider the action of the GABAa neurotransmitter, which, in its dependence on the intracellular level of Cl^-, can change its effect from inhibitory to excitatory. We have developed a computational model that represents the dentate gyrus and is composed of three different populations of neurons (granule cells, interneurons and mossy cells) that are mutually interconnected. The interconnections of the neurons were based on compensation theory with Hebbian and anti-Hebbian rules. The model also incorporates non-synaptic mechanisms to control the ionic homeostasis and was able to reproduce ictal discharg

SUBMITTER: Franca KLA 

PROVIDER: S-EPMC5843660 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature