From "Gut Feeling" to Objectivity: Machine Preservation of the Liver as a Tool to Assess Organ Viability.

ABSTRACT:

Purpose of review

The purpose of this review was to summarise how machine perfusion could contribute to viability assessment of donor livers.

Recent findings

In both hypothermic and normothermic machine perfusion, perfusate transaminase measurement has allowed pretransplant assessment of hepatocellular damage. Hypothermic perfusion permits transplantation of marginal grafts but as yet has not permitted formal viability assessment. Livers undergoing normothermic perfusion have been investigated using parameters similar to those used to evaluate the liver in vivo. Lactate clearance, glucose evolution and pH regulation during normothermic perfusion seem promising measures of viability. In addition, bile chemistry might inform on cholangiocyte viability and the likelihood of pos

SUBMITTER: Watson CJE 

PROVIDER: S-EPMC5843692 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature