Resolvin E1, resolvin D1 and resolvin D2 inhibit constriction of rat thoracic aorta and human pulmonary artery induced by the thromboxane mimetic U46619.

ABSTRACT:

Background and purpose

The ω-6 fatty acid-derived lipid mediators such as prostanoids, thromboxane and leukotrienes have well-established roles in regulating both inflammation and smooth muscle contractility. Resolvins are derived from ω-3 fatty acids and have important roles in promoting the resolution of inflammation, but their activity on smooth muscle contractility is unknown. We investigated whether resolvin E1 (RvE1), resolvin D1 (RvD1) and resolvin D2 (RvD2) can modulate contractions of isolated segments of rat thoracic aorta (RTA) or human pulmonary artery (HPA) induced by the α₁ -adrenoceptor agonist phenylephrine or the stable thromboxane A₂ mimetic U46619.

Experimental approach

Contractile responses in RTA and HPA were measured using wire myo

SUBMITTER: Jannaway M 

PROVIDER: S-EPMC5843708 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature