Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function.

ABSTRACT:

Background and purpose

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract, and an impaired immune response plays a critical role in IBD. The current drugs and therapies for IBD treatment are of limited use, therefore, there is a need to find novel drugs or therapies for this disease. We investigated the effect of cambogin in a mouse model of dextran sulphate sodium (DSS)-induced colitis and whether cambogin attenuates inflammation via a Treg-cell-mediated effect on the immune response.

Experimental approach

Chronic colitis was established in mice using 2% DSS, and cambogin (10 mg·kg^-1 , p.o.) was administered for 10 days. Body weight, colon length and colon histology were assessed. Cytokine production wa

SUBMITTER: Lu Y 

PROVIDER: S-EPMC5843713 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature