DATATOC: a novel conjugate for kit-type ⁶⁸Ga labelling of TOC at ambient temperature.

ABSTRACT:

Background

The widespread acceptance and application of ⁶⁸Ga-PET depends on our ability to develop radiopharmaceuticals that can be prepared in a convenient and suitable manner. A kit-type labelling protocol provides such characteristics and requires chelators that can be radiolabelled under exceptionally mild conditions. Recently the DATA chelators have been introduced that fulfil these requirements. In continuing their development, the synthesis and radiolabelling of the first DATA bifunctional chelator (BFC) and peptide conjugate are described.

Results

A BFC derived from the DATA ligand (2,2'-(6-((carboxymethyl)amino)-1,4-diazepane-1,4-diyl)diacetic acid) has been synthesised in five steps from simple building blocks, with an overall yield of 8 %. DATA^M5</

SUBMITTER: Seemann J 

PROVIDER: S-EPMC5843802 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature