⁴⁴Sc for labeling of DOTA- and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations.

ABSTRACT:

Background

Recently, ⁴⁴Sc (T_1/2 = 3.97 h, Eβ⁺_av = 632 keV, I = 94.3 %) has emerged as an attractive radiometal candidate for PET imaging using DOTA-functionalized biomolecules. The aim of this study was to investigate the potential of using NODAGA for the coordination of ⁴⁴Sc. Two pairs of DOTA/NODAGA-derivatized peptides were investigated in vitro and in vivo and the results obtained with ⁴⁴Sc compared with its ⁶⁸Ga-labeled counterparts.DOTA-RGD and NODAGA-RGD, as well as DOTA-NOC and NODAGA-NOC, were labeled with ⁴⁴Sc and ⁶⁸Ga, respectively. The radiopeptides were investigated with regard to their stability in buffer solution and under metal challenge conditions using Fe³⁺

SUBMITTER: Domnanich KA 

PROVIDER: S-EPMC5843811 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature