Irbesartan prevents sodium channel remodeling in a canine model of atrial fibrillation.

ABSTRACT:

Introduction

Activation of the renin-angiotensin system (RAS) plays an important role in atrial electrical remodeling (AER). The purpose of the present study was to evaluate the effects of irbesartan on cardiac sodium current (I_Na) in a canine model of atrial fibrillation.

Materials and methods

Eighteen dogs were randomized into sham, pacing or pacing+irbesartan groups ( n = 6 in each group). The dogs in the pacing and irbesartan group were paced at 500 bpm for two weeks. Irbesartan (60 mg·kg^-1·d^-1) was administered orally in the pacing+irbesartan groups. I_Na was recorded using the whole-cell patch clamp technique from canine atrial myocytes. The expressions of cardiac Na⁺ channels (Nav1.5) mRNA were semi-quantified by r

SUBMITTER: Wang X 

PROVIDER: S-EPMC5843850 | biostudies-literature | 2018 Jan-Mar

REPOSITORIES: biostudies-literature