Association of seven renin angiotensin system gene polymorphisms with restenosis in patients following coronary stenting.

ABSTRACT:

Background and objective

Percutaneous coronary intervention, despite being effective for coronary revascularization, causes in-stent restenosis due to neointimal hyperplasia in a large number of patients. The renin-angiotensin system is involved in neointimal hyperplasia. This study sought to evaluate seven gene polymorphisms of key renin-angiotensin system components, including angiotensinogen, angiotensin-converting enzyme and angiotensin II type 1a receptors, and their associations with in-stent restenosis in patients with coronary artery disease following coronary stenting.

Methods and results

Three hundred and fifty-two patients undergoing coronary drug-eluting stent implantation were recruited. Seventy-five patients (21.3%) were diagnosed as restenosis by angiography.

SUBMITTER: Zhu M 

PROVIDER: S-EPMC5843879 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature