Association of the polymorphism 12109g>A from the REN gene as a risk factor for preterm birth.

ABSTRACT:

Introduction

Preterm birth is the most important cause of neonatal mortality and morbidity. It is a multifactorial disease with different etiologies, including genetic factors. Genetic variability is represented by single nucleotide polymorphisms (SNPs) in genes of proteins involved in the contractile activity. We determine the association between SNP 12109G> A in REN associated with preterm birth and premature rupture of membrane.

Materials and methods

A study of cases ( N=112, 22-36 weeks of gestation; mean: 31, 95% confidence interval 30.7-32.2) and controls ( N=66; 38-40 weeks of gestation from the last menstrual period; mean: 39.8, 95% confidence interval 38.9-39.4) was performed. Genomic DNA was isolated in all patients from peripheral blood. The SNP 12109G> A ( Mbo I)

SUBMITTER: Rodriguez-Sanchez IP 

PROVIDER: S-EPMC5843887 | biostudies-literature | 2016 Oct-Dec

REPOSITORIES: biostudies-literature