Plasma renin activity in patients with heart failure and reduced ejection fraction on optimal medical therapy.

ABSTRACT:

Background

Renin-angiotensin-aldosterone system (RAAS) activation in heart failure with reduced ejection fraction (HFREF) is detrimental through promotion of ventricular remodeling and salt and water retention.

Aims

The aims of this article are to describe RAAS activity in distinct HFREF populations and to assess its prognostic impact.

Methods

Venous blood samples were prospectively obtained in 76 healthy volunteers, 72 patients hospitalized for acute decompensated HFREF, and 78 ambulatory chronic HFREF patients without clinical signs of congestion. Sequential measurements were performed in patients with acute decompensated HFREF.

Results

Plasma renin activity (PRA) was significantly higher in ambulatory chronic HFREF (7.6 ng/ml/h (2.2; 18.1)) compared to patie

SUBMITTER: Nijst P 

PROVIDER: S-EPMC5843922 | biostudies-literature | 2017 Jul-Sep

REPOSITORIES: biostudies-literature