Haplotype-based association of renin gene polymorphisms with essential hypertension in Han population of northern china.

ABSTRACT:

Introduction

The renin gene has been suggested as a good candidate in the study of genetic mechanism of essential hypertension. However, studies on the contribution of renin gene polymorphisms to essential hypertension, have not had consistent outcomes. The purpose of the present study is to explore the association of renin gene polymorphisms with essential hypertension in the Han population of northern China.

Methods

A case-control study was conducted among 3090 Han farmers (1533 essential hypertension patients and 1557 normotensives). Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and polymerase chain reaction-sequencing.

Results

The genotypic and allelic distributions of rs2368564 in essential hypertension and control

SUBMITTER: Zhang G 

PROVIDER: S-EPMC5843929 | biostudies-literature | 2017 Oct-Dec

REPOSITORIES: biostudies-literature