Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa.

ABSTRACT:

Background

Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of survival in critically ill adults, but little data exist for African children living in malaria-endemic areas.

Methods

In a secondary data analysis of severely ill febrile children included in the Fluid Expansion as Supportive Therapy (FEAST) resuscitation trial, we assessed the association between lactate levels at admission and LC at 8 h with all-cause mortality at 72 h (d72). LC was defined as a relative lactate decline ≥ 40% and/or lactate normalisation (lactate < 2.5 mmol/L).

Results

Of 3170 children in the FEAST trial, including 1719 children (57%)

SUBMITTER: Aramburo A 

PROVIDER: S-EPMC5844084 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature