Increased glycine-amidated hyocholic acid correlates to improved early weight loss after sleeve gastrectomy.

ABSTRACT:

Background

Bile acids (BAs) are post-prandial hormones that play an important role in glucose and lipid homeostasis as well as energy expenditure. Total and glycine-amidated BAs increase after sleeve gastrectomy (SG) and correlate to improved metabolic disease. No specific bile acid subtype has been shown conclusively to mediate the weight loss effect. Therefore, the objective of this study was to prospectively evaluate the comprehensive changes in meal-stimulated BAs after SG and determine if a specific change in the BA profile correlates to the early weight loss response.

Methods

Patients were prospectively enrolled at the University of Nebraska Medical Center who were undergoing a SG for treatment of morbid obesity. Primary and secondary plasma bile acids and their amidat

SUBMITTER: Kindel TL 

PROVIDER: S-EPMC5844265 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature