Tools Allowing Independent Visualization and Genetic Manipulation of <i>Drosophila melanogaster</i> Macrophages and Surrounding Tissues.

ABSTRACT: Drosophila melanogaster plasmatocytes, the phagocytic cells among hemocytes, are essential for immune responses, but also play key roles from early development to death through their interactions with other cell types. They regulate homeostasis and signaling during development, stem cell proliferation, metabolism, cancer, wound responses, and aging, displaying intriguing molecular and functional conservation with vertebrate macrophages. Given the relative ease of genetics in Drosophila compared to vertebrates, tools permitting visualization and genetic manipulation of plasmatocytes and surrounding tissues independently at all stages would greatly aid a fuller understanding of these processes, but are lacking. Here, we describe a comprehensive set of transgenic lines that allo

SUBMITTER: Gyoergy A 

PROVIDER: S-EPMC5844306 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature