Tuning CRISPR-Cas9 Gene Drives in Saccharomyces cerevisiae.

ABSTRACT: Control of biological populations is an ongoing challenge in many fields, including agriculture, biodiversity, ecological preservation, pest control, and the spread of disease. In some cases, such as insects that harbor human pathogens (e.g., malaria), elimination or reduction of a small number of species would have a dramatic impact across the globe. Given the recent discovery and development of the CRISPR-Cas9 gene editing technology, a unique arrangement of this system, a nuclease-based "gene drive," allows for the super-Mendelian spread and forced propagation of a genetic element through a population. Recent studies have demonstrated the ability of a gene drive to rapidly spread within and nearly eliminate insect populations in a laboratory setting. While there are still ongoing

SUBMITTER: Roggenkamp E 

PROVIDER: S-EPMC5844318 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature