The Y Chromosome Modulates Splicing and Sex-Biased Intron Retention Rates in Drosophila.

ABSTRACT: The Drosophila Y chromosome is a 40-Mb segment of mostly repetitive DNA; it harbors a handful of protein-coding genes and a disproportionate amount of satellite repeats, transposable elements, and multicopy DNA arrays. Intron retention (IR) is a type of alternative splicing (AS) event by which one or more introns remain within the mature transcript. IR recently emerged as a deliberate cellular mechanism to modulate gene expression levels and has been implicated in multiple biological processes. However, the extent of sex differences in IR and the contribution of the Y chromosome to the modulation of AS and IR rates has not been addressed. Here we showed pervasive IR in the fruit fly Drosophila melanogaster with thousands of novel IR events, hundreds of which displayed extensi

SUBMITTER: Wang M 

PROVIDER: S-EPMC5844322 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature