In vivo photoacoustic imaging of chorioretinal oxygen gradients.

ABSTRACT: Chorioretinal imaging has a crucial role for the patients with chorioretinal vascular diseases, such as neovascular age-related macular degeneration. Imaging oxygen gradients in the eye could better diagnose and treat ocular diseases. Here, we describe the use of photoacoustic ocular imaging (PAOI) in measuring chorioretinal oxygen saturation (CR  -  sO2) gradients in New Zealand white rabbits (n  =  5) with ocular ischemia. We observed good correlation (R2  =  0.98) between pulse oximetry and PAOI as a function of different oxygen percentages in inhaled air. We then used an established ocular ischemia model in which intraocular pressure is elevated to constrict ocular blood flow, and notice a positive correlation (R2  =  0.92) between the injected volume of phosphate buffered saline (PBS)

SUBMITTER: Hariri A 

PROVIDER: S-EPMC5844348 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature