Prognostic indices of inflammatory markers, cognitive function and fatigue for survival in patients with localised colorectal cancer.

ABSTRACT:

Background

Inflammation promotes the development of malignancy, while a variety of systemic markers of inflammation predict for worse cancer outcomes including recurrence and survival. Here, we evaluate the prognostic impact of cytokine concentrations, full blood count (FBC) differential ratios, cognitive function and fatigue on survival in patients with localised colorectal cancer (CRC).

Patients and methods

Data are from a prospective longitudinal study comparing cognitive function and fatigue in patients with CRC who did (n=173) and did not (n=116) receive adjuvant/neoadjuvant chemotherapy. Baseline blood results (prior to any chemotherapy) included cytokines and FBC from which neutrophil lymphocyte ratio, lymphocyte monocyte ratio, platelet lymphocyte ratio and platelet

SUBMITTER: Vardy JL 

PROVIDER: S-EPMC5844380 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature