Chemically Defined Antibody- and Small Molecule-Drug Conjugates for in Vivo Tumor Targeting Applications: A Comparative Analysis.

ABSTRACT: We present the first direct comparative evaluation of an antibody-drug conjugate and of a small molecule-drug conjugate for cancer therapy, using chemically defined products which bind with high-affinity to carbonic anhydrase IX, a marker of tumor hypoxia and of renal cell carcinoma.

SUBMITTER: Cazzamalli S 

PROVIDER: S-EPMC5844464 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature