Ontology highlight
ABSTRACT:
SUBMITTER: Rhoads TW
PROVIDER: S-EPMC5844481 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Rhoads Timothy W TW Burhans Maggie S MS Chen Vincent B VB Hutchins Paul D PD Rush Matthew J P MJP Clark Josef P JP Stark Jaime L JL McIlwain Sean J SJ Eghbalnia Hamid R HR Pavelec Derek M DM Ong Irene M IM Denu John M JM Markley John L JL Coon Joshua J JJ Colman Ricki J RJ Anderson Rozalyn M RM
Cell metabolism 20180301 3
Caloric restriction (CR) extends lifespan and delays the onset of age-related disorders in diverse species. Metabolic regulatory pathways have been implicated in the mechanisms of CR, but the molecular details have not been elucidated. Here, we show that CR engages RNA processing of genes associated with a highly integrated reprogramming of hepatic metabolism. We conducted molecular profiling of liver biopsies collected from adult male rhesus monkeys (Macaca mulatta) at baseline and after 2 year ...[more]