Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys.

ABSTRACT: Caloric restriction (CR) extends lifespan and delays the onset of age-related disorders in diverse species. Metabolic regulatory pathways have been implicated in the mechanisms of CR, but the molecular details have not been elucidated. Here, we show that CR engages RNA processing of genes associated with a highly integrated reprogramming of hepatic metabolism. We conducted molecular profiling of liver biopsies collected from adult male rhesus monkeys (Macaca mulatta) at baseline and after 2 years on control or CR (30% restricted) diet. Quantitation of over 20,000 molecules from the hepatic transcriptome, proteome, and metabolome indicated that metabolism and RNA processing are major features of the response to CR. Predictive models identified lipid, branched-chain amino acid, and short-cha

SUBMITTER: Rhoads TW 

PROVIDER: S-EPMC5844481 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature