Flexibility-rigidity index for protein-nucleic acid flexibility and fluctuation analysis.

ABSTRACT: Protein-nucleic acid complexes are important for many cellular processes including the most essential functions such as transcription and translation. For many protein-nucleic acid complexes, flexibility of both macromolecules has been shown to be critical for specificity and/or function. The flexibility-rigidity index (FRI) has been proposed as an accurate and efficient approach for protein flexibility analysis. In this article, we introduce FRI for the flexibility analysis of protein-nucleic acid complexes. We demonstrate that a multiscale strategy, which incorporates multiple kernels to capture various length scales in biomolecular collective motions, is able to significantly improve the state of art in the flexibility analysis of protein-nucleic acid complexes. We take the advantage of

SUBMITTER: Opron K 

PROVIDER: S-EPMC5844491 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature