Ontology highlight
ABSTRACT:
SUBMITTER: Serroukh Y
PROVIDER: S-EPMC5844691 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Serroukh Yasmina Y Gu-Trantien Chunyan C Hooshiar Kashani Baharak B Defrance Matthieu M Vu Manh Thien-Phong TP Azouz Abdulkader A Detavernier Aurélie A Hoyois Alice A Das Jishnu J Bizet Martin M Pollet Emeline E Tabbuso Tressy T Calonne Emilie E van Gisbergen Klaas K Dalod Marc M Fuks François F Goriely Stanislas S Marchant Arnaud A
eLife 20180228
Cytotoxic CD4 (CD4<sub>CTX</sub>) T cells are emerging as an important component of antiviral and antitumor immunity, but the molecular basis of their development remains poorly understood. In the context of human cytomegalovirus infection, a significant proportion of CD4 T cells displays cytotoxic functions. We observed that the transcriptional program of these cells was enriched in CD8 T cell lineage genes despite the absence of ThPOK downregulation. We further show that establishment of CD4<s ...[more]