Metabolic characteristics of solid pseudopapillary neoplasms of the pancreas: their relationships with high intensity ¹⁸F-FDG PET images.

ABSTRACT:

Objective

We aimed to investigate the metabolic characteristics of Solid pseudopapillary neoplasms (SPNs) in relation signal intensities on ¹⁸F-FDG PET scans.

Summary background data

SPNs of the pancreas commonly show high uptake of 18F-FDG. However, the metabolic characteristics underlying the high ¹⁸F-FDG uptake in SPNs are not well characterized.

Materials and methods

mRNA expressions for glucose metabolism were analyzed in five SPNs, five pancreatic ductal adenocarcinomas (PCAs), and paired normal pancreatic tissues. Among the proteins involved in glucose metabolism, the expressions of five proteins (GLUT1, HK1, PFKM, ENO2, and PKM2) were evaluated in 36 SPNs by immunohistochemistry. Clinical patterns of SPN on PET scans were classified accor

SUBMITTER: Park M 

PROVIDER: S-EPMC5844725 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature