Immunodominant antigens that induce Th1 and Th17 responses protect mice against Helicobacter pylori infection.

ABSTRACT: Helicobacter pylori has infected more than half of the world's population, causing gastritis, gastric ulcers, gastric mucosa-associated lymphoid tissue lymphoma and gastric cancer. The oral recombinant Helicobacter pylori vaccine currently used has made great progress in addressing this problem, however, its efficacy and longevity still need to be improved. Th1 and Th17 cells play essential roles in local protection against Helicobacter pylori in the stomach mucosa. Additionally, protective immunodominant antigens are the preferred for a vaccine. In this work, Helicobacter pylori whole cell lysate was separated into 30 groups based on molecular weight by molecular sieve chromatography. The group best promoting CD4 T cells proliferation was selected and evaluated

SUBMITTER: Sun H 

PROVIDER: S-EPMC5844728 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature