Immunoclassification characterized by CD8 and PD-L1 expression is associated with the clinical outcome of gastric cancer patients.

ABSTRACT:

Background

Gastric cancer (GC) is a major cause of cancer deaths, especially in Eastern Asia. Current classification systems, including the WHO, Lauren, and TCGA, have clarified the pathological and molecular profiles of GC. However, these classifications lack an association with clinical outcome and guidance for medication selection.

Objective

We aimed to identify a new immunoclassification for GC to better predict patient prognosis and aid in patient selection for immunotherapy.

Results

For all samples, 35 were EBV positive (+) and 112 were EBV negative (-). EBV infection was associated with the number of CD3+ T cells (OR = 2.91 95% CI 1.27-6.68, p = 0.012) and PD-L1 expression in TME (OR = 2.57, 95% CI 1.13-5.82, p = 0.024). EBV+ patients showed a poo

SUBMITTER: Wang W 

PROVIDER: S-EPMC5844736 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature