The Inflammatory Potential of Dietary Manganese in a Cohort of Elderly Men.

ABSTRACT: Manganese is an essential nutrient that may play a role in the production of inflammatory biomarkers. We examined associations between estimated dietary manganese intake from food/beverages and supplements with circulating biomarkers of inflammation. We further explored whether estimated dietary manganese intake affects DNA methylation of selected genes involved in the production of these biomarkers. We analyzed 1023 repeated measures of estimated dietary manganese intakes and circulating blood inflammatory biomarkers from 633 participants in the Normative Aging Study. Using mixed-effect linear regression models adjusted for covariates, we observed positive linear trends between estimated dietary manganese intakes and three circulating interleukin proteins. Relative to the lowest quartile

SUBMITTER: Kresovich JK 

PROVIDER: S-EPMC5844859 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature