Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice.

ABSTRACT: AIM/HYPOTHESIS:Adiponectin (APN), a circulating hormone secreted by mature adipocytes, has been extensively studied because it has beneficial metabolic effects. While many studies have focused on the congenital loss of APN and its effects on systemic body glucose and lipid metabolism, little is known about the effects triggered by acute loss of APN in the adult mouse. We anticipated that genetically induced acute depletion of APN in adult mice would have a more profound effect on systemic metabolic health than congenital deletion of Adipoq, the gene encoding APN, with its associated potential for adaptive responses that may mask the phenotypes. METHODS:Mice carrying loxP-flanked regions of Adipoq were generated and bred to the Adipoq (APN) promoter-driven reverse tetracycline-controlled tr

SUBMITTER: Xia JY 

PROVIDER: S-EPMC5844860 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature