Phenolic compounds as antioxidants and chemopreventive drugs from Streptomyces cellulosae strain TES17 isolated from rhizosphere of Camellia sinensis.

ABSTRACT:

Background

Oxidative stress in an intracellular environment created by the accumulation of reactive oxygen species results in oxidative damage to biomolecules which ultimately become a hallmark for severe diseases like cancer, aging, diabetes, and cardiovascular and neurodegenerative diseases.

Methods

Various in vitro assays were employed to assess the antioxidant potential of strain, DNA protective activity was demonstrated using DNA nicking assay and cytotoxicity of the extract was evaluated using MTT assay. Further identification of the compounds was done using UPLC analysis.

Results

The extract of Streptomyces cellulosae strain TES17 demonstrated significant antioxidant activity with percentage inhibition of 78.47 ± 0.23, 91.08 ± 0.98 and 82.08 ± 0.93 for DPPH, AB

SUBMITTER: Rani R 

PROVIDER: S-EPMC5845325 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature