HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues.

ABSTRACT:

Background

Expression quantitative trait loci (eQTL) analysis identifies genetic markers associated with the expression of a gene. Most existing eQTL analyses and methods investigate association in a single, readily available tissue, such as blood. Joint analysis of eQTL in multiple tissues has the potential to improve, and expand the scope of, single-tissue analyses. Large-scale collaborative efforts such as the Genotype-Tissue Expression (GTEx) program are currently generating high quality data in a large number of tissues. However, computational constraints limit genome-wide multi-tissue eQTL analysis.

Results

We develop an integrative method under a hierarchical Bayesian framework for eQTL analysis in a large number of tissues. The model fitting procedure is highly scala

SUBMITTER: Li G 

PROVIDER: S-EPMC5845327 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature