Mouse papillomavirus infections spread to cutaneous sites with progression to malignancy.

ABSTRACT: We report secondary cutaneous infections in the mouse papillomavirus (MmuPV1)/mouse model. Our previous study demonstrated that cutaneous MmuPV1 infection could spread to mucosal sites. Recently, we observed that mucosal infections could also spread to various cutaneous sites including the back, tail, muzzle and mammary tissues. The secondary site lesions were positive for viral DNA, viral capsid protein and viral particles as determined by in situ hybridization, immunohistochemistry and transmission electron microscopy analyses, respectively. We also demonstrated differential viral production and tumour growth at different secondarily infected skin sites. For example, fewer viral particles were detected in the least susceptible back tissues when compared with those in the infected

SUBMITTER: Cladel NM 

PROVIDER: S-EPMC5845569 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature