A manganese photosensitive tricarbonyl molecule [Mn(CO)3(tpa-κ³N)]Br enhances antibiotic efficacy in a multi-drug-resistant Escherichia coli.

ABSTRACT: Carbon monoxide-releasing molecules (CORMs) are a promising class of new antimicrobials, with multiple modes of action that are distinct from those of standard antibiotics. The relentless increase in antimicrobial resistance, exacerbated by a lack of new antibiotics, necessitates a better understanding of how such novel agents act and might be used synergistically with established antibiotics. This work aimed to understand the mechanism(s) underlying synergy between a manganese-based photoactivated carbon monoxide-releasing molecule (PhotoCORM), [Mn(CO)3(tpa-κ³N)]Br [tpa=tris(2-pyridylmethyl)amine], and various classes of antibiotics in their activities towards Escherichia coli EC958, a multi-drug-resistant uropathogen. The title compound acts synergistically with polymyxins [po

SUBMITTER: Rana N 

PROVIDER: S-EPMC5845575 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature