Secretoneurin A Directly Regulates the Proteome of Goldfish Radial Glial Cells In Vitro.

ABSTRACT: Radial glial cells (RGCs) are the main macroglia in the teleost brain and have established roles in neurogenesis and neurosteroidogenesis. They are the only brain cell type expressing aromatase B (cyp19a1b), the enzyme that synthesizes estrogens from androgen precursors. There are few studies on the regulation of RGC functions, but our previous investigations demonstrated that dopamine stimulates cyp19a1b expression in goldfish RGCs, while secretoneurin A (SNa) inhibits the expression of this enzyme. Here, we determine the range of proteins and cellular processes responsive to SNa treatments in these steroidogenic cells. The focus here is on SNa, because this peptide is derived from selective processing of secretogranin II in magnocellular cells embedded within the RGC-rich p

SUBMITTER: Da Fonte DF 

PROVIDER: S-EPMC5845582 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature