HMGA1 is a novel transcriptional regulator of the FoxO1 gene.

ABSTRACT:

Purpose

The forkhead transcription factor (FoxO1) is a master transcriptional regulator of fundamental cellular processes ranging from cell proliferation and differentiation to inflammation and metabolism. However, despite its relevance, the mechanism(s) underlying FoxO1 gene regulation are largely unknown. We have previously shown that the chromatin factor high-mobility group A1 (HMGA1) plays a key role in the transcriptional regulation of glucose-responsive genes, including some that are involved in FoxO1-mediated glucose metabolism. Here we investigated the impact of HMGA1 on FoxO1 gene expression.

Methods

FoxO1 protein and gene expression studies were performed by Western blot analysis combined with qRT-PCR of material from human cultured cells and EBV-transformed lympho

SUBMITTER: Arcidiacono B 

PROVIDER: S-EPMC5845622 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature