The cellular endosomal protein stannin inhibits intracellular trafficking of human papillomavirus during virus entry.

ABSTRACT: Human papillomaviruses (HPVs) are the most common sexually transmitted viruses and one of the most important infectious causes of cancers worldwide. While prophylactic vaccines are effective against certain strains of HPV, established infections still cause deadly cancers in both men and women. HPV traffics to the nucleus via the retrograde transport pathway, but the mechanism of intracellular transport of non-enveloped viruses such as HPV is incompletely understood. Using an overexpression screen, we identify several genes that control HPV16 entry. We focused on the mechanism by which one of the screen hits, stannin, blocks HPV16 infection. Stannin has not been previously implicated in virus entry. Overexpression of stannin specifically inhibits infection by several HPV types, but not oth

SUBMITTER: Lipovsky A 

PROVIDER: S-EPMC5845663 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature