Cefepime Efficacy and Safety in Children: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Cefepime is a fourth-generation cephalosporin antibiotic used to treat a variety of infections. The US Food and Drug Administration approved its use in certain types of infections among pediatric patients, and yet there have been mixed data about its efficacy and safety in this population.

Objective

The objective of this review is to compare efficacy and all-cause mortality of cefepime to other clinically indicated antibiotics among children.

Methods

We conducted a systematic search of MEDLINE, EMBASE, CENTRAL, LILACS, and clinicaltrials.gov databases through February 8, 2016. We included randomized controlled trials comparing cefepime to other clinical antibiotics, placebo, or no treatment in children aged 0-19 years in the inpatient setting with clinical

SUBMITTER: Jan S 

PROVIDER: S-EPMC5845692 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature