The Agrobacterium tumefaciens CheY-like protein ClaR regulates biofilm formation.

ABSTRACT: The switch from a motile, planktonic existence to an attached biofilm is a major bacterial lifestyle transition that is often mediated by complex regulatory pathways. In this report, we describe a CheY-like protein required for control of the motile-to-sessile switch in the plant pathogen Agrobacterium tumefaciens. This regulator, which we have designated ClaR, possesses two distinct CheY-like receiver (REC) domains and is involved in the negative regulation of biofilm formation, through production of the unipolar polysaccharide (UPP) adhesin and cellulose. The ClaR REC domains share predicted structural homology with characterized REC domains and contain the majority of active site residues known to be essential for protein phosphorylation. REC1 is missing the conserved aspartate (

SUBMITTER: Feirer N 

PROVIDER: S-EPMC5845703 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature