Blood Gene Expression Profile Predicts Response to Antipsychotics.

ABSTRACT: Antipsychotic drugs are one of the largest types of prescribed drugs and have large inter-individual differences in efficacy, but there is no methodology to predict their clinical effect. Here we show a four-gene blood expression profile to predict the response to antipsychotics in schizophrenia patients before treatment. We sequenced total mRNA from blood samples of antipsychotic naïve patients who, after 3 months of treatment, were in the top 40% with the best response (15 patients) and in the bottom 40% with the worst response (15 patients) according to the Brief Psychiatric Rating Scale (BPRS). We characterized the transcriptome before treatment of these 30 patients and found 130 genes with significant differential expression (P_adj value < 0.01) associated with clinic

SUBMITTER: Sainz J 

PROVIDER: S-EPMC5845714 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature