Genetic and childhood trauma interaction effect on age of onset in bipolar disorder: An exploratory analysis.

ABSTRACT:

Introduction

This study investigated whether early life trauma mediates genetic effects on the age at onset (AAO) of bipolar disorder.

Method

Data from the BiGS Consortium case samples (N=1119) were used. Childhood traumatic events were documented using the Childhood Life Events Scale (CLES). Interaction between occurrence of childhood trauma and common genetic variants throughout the genome was tested to identify single nucleotide polymorphic gene variants (SNPs) whose effects on bipolar AAO differ between individuals clearly exposed (CLES≥2) and not exposed (CLES=0) to childhood trauma.

Results

The modal response to the CLES was 0 (N=480), but an additional 276 subjects had CLES=1, and 363 subjects reported 2 or more traumatic lifetime events. The distribution of ag

SUBMITTER: Anand A 

PROVIDER: S-EPMC5845791 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature