Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK.

ABSTRACT:

Background

Hydrogen sulfide (H₂S) is an important regulator of mitochondrial bioenergetics, but its role in regulating mitochondrial biogenesis is not well understood. Using both genetic and pharmacological approaches, we sought to determine if H₂S levels directly influenced cardiac mitochondrial content.

Results

Mice deficient in the H₂S-producing enzyme, cystathionine γ-lyase (CSE KO) displayed diminished cardiac mitochondrial content when compared to wild-type hearts. In contrast, mice overexpressing CSE (CSE Tg) and mice supplemented with the orally active H₂S-releasing prodrug, SG-1002, displayed enhanced cardiac mitochondrial content. Additional analysis revealed that cardiac H₂S levels influenced the nuclear local

SUBMITTER: Shimizu Y 

PROVIDER: S-EPMC5845802 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature