Protection of macrophages from intracellular pathogens by miR-182-5p mimic-a gene expression meta-analysis approach.

ABSTRACT: The goals of this study were to (a) define which host genes are of particular importance during the interactions between macrophages and intracellular pathogens, and (b) use this knowledge to gain fresh, experimental understanding of how macrophage activities may be manipulated during host defense. We designed an in silico method for meta-analysis of microarray gene expression data, and used this to combine data from 16 different studies of cells in the monocyte-macrophage lineage infected with seven different pathogens. Three thousand four hundred ninety-eight genes were identified, which we call the macrophage intracellular pathogen response (macIPR) gene set. As expected, the macIPR gene set showed a strong bias toward genes previously associated with the immune response. Predicted targ

SUBMITTER: Gregory DJ 

PROVIDER: S-EPMC5845812 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature