WNT5A induces castration-resistant prostate cancer via CCL2 and tumour-infiltrating macrophages.

ABSTRACT:

Background

Although the standard treatment for the patients with recurrent and metastatic prostate cancer (CaP) is androgen deprivation therapy, castration-resistant prostate cancer (CRPC) eventually emerges. Our previous report indicated that bone morphogenetic protein 6 (BMP6) induced CRPC via tumour-infiltrating macrophages. In a separate line of study, we have observed that the WNT5A/BMP6 loop in CaP bone metastasis mediates resistance to androgen deprivation in tissue culture. Simultaneously, we have reported that BMP6 induced castration resistance in CaP cells via tumour-infiltrating macrophages. Therefore, our present study aims to investigate the mechanism of WNT5A and its interaction with macrophages on CRPC.

Methods

Doxycycline inducible WNT5A overexpression prosta

SUBMITTER: Lee GT 

PROVIDER: S-EPMC5846063 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature